IBM Lotus Notes/Domino continues to set the standard for innovation in the messaging and collaboration market that Lotus defined over a decade ago. With each release of Notes and Domino, IBM improves the scalability, security, administration, and resource requirements, enabling customers to achieve the most from their infrastructure. Upgrading to the newest releases from earlier ones -- or upgrading from Microsoft Exchange to Lotus Domino -- can help your company to realize the greatest return on investment, potentially lower your cost of ownership, and improve user satisfaction.
Link: Why upgrade to Notes/Domino 6.5.x >

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