Well, it's been more than a month since I wrote anything on this topic, but this case study is too useful to ignore.  It describes how Hyperion migrated a mixed Domino/Exchange environment to Exchange 2003... at a cost of $1.2 million... for 3800 users.  In other words, US$315 per user.  And what did they get?

Hyperion established new mailbox quotas as users were migrated. Notes users, due to the nature of Notes, had been accustomed to large mailbox sizes. "Notes handles mail differently on the back end, so large mailboxes aren't as much of a problem," says Tiseo. Hyperion's new quotas are 300MB for regular users and 800MB for VIP users. To a traditional Exchange shop this seems overly generous, admits Tiseo, but the migration team wanted to avoid culture shock. ...

For high availability, Hyperion runs active/passive Exchange clusters at each regional hub. Hyperion originally intended more complicated multiserver clusters, but found them too difficult, forcing the firm to go with single active/passive pairs for its clusters. "Exchange is not very cluster-aware, and it is not good at automated failback," says Tiseo. The company manually switches Exchange back after a failover. ...

"It costs much more to manage multiple environments and coexistence than the Exchange platform. We've gone from 40 Notes servers to eight Exchange servers with high availability," he says.

The company has virtually eliminated spam, and has established a platform for Windows mobile access and enterprise-wide collaboration. Finally, the messaging team can now promise management that in any future acquisition, "we can give as many as 100 acquired employees their new Hyperion e-mail address on day one," says Tiseo. For a company driven by an acquisition strategy, that may be the biggest payback of all.
Every single thing that the customer describes as a benefit in the Exchange environment was available to them in Notes/Domino 6.x.  Every single challenge described is better-handled in the Notes/Domino environment.  And the paper says nothing about how any existing Notes applications were addressed.

Link: Storage Magazine: Case Study: Moving from Lotus Notes to Microsoft Exchange > (free registration may be required)

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